Metodę tę stosuje się wyłącznie w przypadku próchnicy początkowej przebiegającej w obrębie szkliwa oraz cementu korzeniowego. Demineralizacja polega na zwiększeniu porowatości szkliwa w następstwie rozpuszczenia hydroksyapatytów przez kwasy, które są wyprodukowane przez bakterie lub dostarczone w pożywieniu (kwasy owocowe). Na tym etapie zmiana nie jest widoczna klinicznie.
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